Month: June 2026

Train-the-Trainer course 2026

Do you train others to use light microscopy and would like to improve your training?

Together with Rhonda R. Powell from Clemson University in the USA, I will give the second edition of the online course “Magnify your impact: Train the Microscopy Trainer”.

This practical, interactive, online course is intended for anyone with experience training people to use light microscopes, including Core Facility Staff and Industry Applications Specialists.

During the course, you will focus on improving your OWN training. By the end of the course, you will be able to:

  • Write a list of learning objectives for your own microscopy training
  • Incorporate new pedagogical tools in your microscopy training
  • Evaluate the quality of your training using assessments and feedback

The application page is open until the 1st of August.

SeeDB-Live: Clearing live samples with BSA

Amazing talk at the ELMI in Coimbra!

Takeshi Imai presented SeeDB-Live, a new clearing technique for live samples. The refractive index is 1.363 and the technique works exceptionally well in loose tissues like brain but allows also 2 times deeper imaging in live organoids. They could even image calcium with multiphoton repeatedly over several months in brain of live mice!

The paper was just published in Nature.

FLASH-PAINT: nm resolution, fast and highly multiplexed!

Just heard this amazing Eurobioimaging talk by Florian Shueder from EFPL. They published FLASH-PAINT, an improved version of DNA-Paint.

FLASH-PAINT combined with fluorogenic probes, eraser oligos and EXCHANGE-PAINT has many advantages over DNA-PAINT:

    • It keeps the very high resolution of just a few nm.
    • It is very fast.
    • It enables imaging with a widefield system instead of in TIRF.
    • It enables high multiplexing (they demonstrate 12 rounds) without needing to wash.

They demonstrate 12-plex imaging with 25nm resolution in just 2h!

 

Reproducibility?

Have you ever heard of the Antibody reproducibility crisis?

Well here is a new chapter in this sad saga and this one is about the possible image manipulation of the Western Blots on the datasheets of commercial antibodies.

There is a strong need for clearer ethical guidelines and more education.

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